The SGLPT2 Inhibitors: Pro’s and Con’s

The SGLPT2 inhibitors are the newest class of drugs used to treat people with diabetes.

They work by inhibiting reabsorption of sugar from the kidneys by the SGLPT2 transporters.

Since these transporters account for 90% of sugar reabsorption, their blockage results in significant loss of sugar in the urine. This effect is independent of insulin.

Clinically, this results in lower sugar levels in the blood, both before and after meals. The average HA1c reduction is 0.7-1.2% in studies ranging from 4-90 weeks.

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Type 2 Diabetes – The Connection Between Low Levels of Various Amino Acids and Insulin Sensitivity


Some research is so basic it will be some time before it yields practical value, but it is interesting to see what is going on in the field. In November 2014 the Journal of Clinical Endocrinology and Metabolism reported on a study of various amino acids, sensitivity to insulin, and the development of Type 2 diabetes.

The study included 196 participants from various ethnic groups. Sixty-nine types of molecules found in the bloodstream were compared in people with high and low insulin sensitivity. It was found the people with low insulin sensitivity tended to have lower concentrations of the amino acids glycine, valine, leucine, phenylalanine, glutamine, and glutamate than the individuals with high insulin sensitivity. The association was particularly strong in individuals with European backgrounds. The participants who developed Type 2 diabetes tended to have low levels of the same amino acids. This was not surprising, since insulin resistance is the hallmark of Type 2 diabetes.

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Type 2 Diabates – Exercise Is Key for Improving Insulin Sensitivity

Exercise is beneficial for people with Type 2 diabetes in several ways. Besides helping keep your blood sugar levels under control and helping you lose weight, exercising also can improve insulin sensitivity.

When you exercise, insulin moves sugar from the blood to the large muscles of your body where it’s needed for energy. Even if you have Type 2 diabetes and your body either doesn’t produce enough insulin or doesn’t respond to it well, when you exercise your body is able to use insulin better. This happens even after one session of exercise! If you aren’t exercising now, after your first exercise session glucose will be able to move into your cells 40 percent better than before you commenced exercising.

The effect of exercise on insulin is even better and longer-lasting if you’re able to lose weight too. If you’re overweight, losing body fat through exercising helps your body become more sensitive to insulin for four days or more after exercise. So if you can exercise regularly and lose weight, your body will be more sensitive to insulin all the time. You may even be able to reverse your Type 2 diabetes!

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The Best Treatment for Gestational Diabetes

Insulin is considered the mainstay of gestational diabetes, but treatment protocols change as new information is gathered. Metformin has become the first drug of choice for people diagnosed with diabetes since its introduction in 1994 and could replace or be added to insulin for treating gestational diabetes.

Investigators at Dow University of Health Sciences together with other research institutions in Karachi, Pakistan, compared…

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The Different Types of Sugar to Watch Out For

As a Type 2 diabetic you are naturally aware of the importance of checking food labels to see how much carbohydrate is in your food. It’s also a good idea to read the ingredient list and see what’s contributing to the amount of carbohydrates in the food. Are they natural sugars from milk or fruit? Or are they one of the many types of added sugars? To identify added sugars in your food, it can be helpful to understand all the different names for sugar.

1. High fructose corn syrup. This is a sugar made from corn. It’s used to sweeten many sodas, fruit-flavored drinks, and more. You may also see other types of syrups on ingredient lists and these are also types of sugar.

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